Similarly incorporation of 2H from 2H 2O into cholesterol ester, free fatty acids or triglycerides can be used to determine the synthetic rates of lipid turnover. This 2H 2O technique has been used to measure the synthesis of proteins in muscle, bone, liver, lung and other tissues Protein synthesis can be conveniently measured by use of a continuous label administration, rise-to-plateau approach, based on the incorporation of deuterium ( 2H) from heavy water ( 2H 2O) into nonessential amino acids (NEAA) in newly synthesized proteins using heavy water in human tissue and have also measured kinetics of complex lipids (e.g. , triglycerides, fatty acids and cholesterol We have previously developed methods to measure the kinetics of keratin Therefore there may be significant changes in lipid kinetics in psoriatic individuals reflecting this defect in lipid homeostasis. Psoriatic skin displays abnormal expression and abnormal location/distribution of lipids, and this appears to be at least partly related to disease severity. The stratum cornea is enriched with organized layers of intercellular lipids composed primarily of ceramides, cholesterol and fatty acids Skin lipid content is particularly critical for maintaining skin barrier function and regulating water loss. Abnormal epidermal turnover can impair skin barrier function and tissue repair hence keratinocyte or keratin turnover may be critical in disorders of the skin as well as in response to therapyĭislipidemia is a further co-morbidity in this systemic disease. Due to the hyper-proliferation and hyper-keratinization observed in psoriatic skin, there has been substantial work examining epidermal keratinocyte and keratin dynamics.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |